During my childhood I had a rough time with anxiety and had ulcers as a result. When I was taken to the doctors I was given antibiotics for my ulcer and belladonna for my anxiety. I generally am not a fan of any kind of medicine, being that natural or pharmaceutical but I tried them anyways. Belladonna comes from a toxic plant and has been used for anything from motion sickness to menstrual cramps. I only took it a couple of times and it did, indeed relax me, almost made me sleepy. I'm definitely not condoning it, but rather, being open-minded.
Taboo as it can be, natural drugs come in many forms with multple effects. They started with the purpose of healing or curing, and all the way up to mind-altering. I always wonder, who was the first person to light up a plant or shove it up the nose? Regardless, in my opinion drugs are used as a way to escape. Whether your life sucks, or you just want to see the world in a new way it is escapism at its finest.